Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• applications. Keywords: curcumin; human pulmonary mucus; microfluidics; muco-penetrating nanoparticles; nanomedicine; permeability; PLGA nanoparticles; Introduction In the last decades, the application of nanotechnology in medicine has gained significant attention, especially in the biomedical field for

• to address strong and continuous inflammatory responses which could have an impact in, for example, cystic fibrosis treatment [38]. The potential for application in cystic fibrosis treatment was highlighted monitoring the penetration of the particles through human pulmonary mucus. Results and

• investigate if the increase in PDI has a negative influence of the mucus penetration, the diffusion of Pluronic F68 stabilized particles with different sizes was analyzed. Permeability of NPs through human pulmonary mucus The interaction of NPs with mucin is a crude estimate for the interaction with mucus